Bayesian Mass Spectra Peak Alignment from Mass Charge Ratios
نویسندگان
چکیده
منابع مشابه
Bayesian Mass Spectra Peak Alignment from Mass Charge Ratios
Proteomics studies based on mass spectrometry (MS) are gaining popular applications in biomedical research for protein identification/quantification and biomarker discovery, especially for potential early diagnosis and prognosis of severe disease before the occurrence of symptoms. However, MS data collected using current technologies are very noisy and appropriate data preprocessing is critical...
متن کاملImproving mass spectrometry peak detection using multiple peak alignment results.
Mass spectrometry data are often corrupted by noise. It is very difficult to simultaneously detect low-abundance peaks and reduce false-positive peak detection caused by noise. In this paper, we propose to improve peak detection using an additional constraint: the consistent appearance of similar true peaks across multiple spectra. We observe that false -positive peaks in general do not repeat ...
متن کاملSelf-Calibrated Warping for Mass Spectra Alignment
With recent advances in mass spectrometry (MS) technologies, it is now possible to study protein profiles over a wide range of molecular weights in small biological specimens. However, MS spectra are usually not aligned or synchronized between samples. To ensure the consistency of the subsequent analysis, spectrum alignment is necessary to align the spectra such that the same biological entity ...
متن کاملAutomated charge state determination of complex isotope-resolved mass spectra by peak-target Fourier transform.
This study describes a new algorithm for charge state determination of complex isotope-resolved mass spectra. This algorithm is based on peak-target Fourier transform (PTFT) of isotope packets. It is modified from the widely used Fourier transform method because Fourier transform may give ambiguous charge state assignment for low signal-to-noise ratio (S/N) or overlapping isotopic clusters. The...
متن کاملCoulomb bicrystals of species with identical charge-to-mass ratios.
Structures of cold bicomponent Coulomb systems of particles with identical charge-to-mass ratios and common oscillation frequency in a spherical harmonic potential are studied by molecular dynamics simulations with up to 10(6) particles. For most initial conditions and cooling rates, the final state becomes a completely mixed core surrounded by a set of nearly degenerated double shells of separ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Informatics
سال: 2008
ISSN: 1176-9351,1176-9351
DOI: 10.1177/117693510800600006